A Seventh-day Adventist Organization

Christopher Perry, PhD

Assistant Professor

Basic Sciences
Division of Biochemistry
School of Medicine
Loma Linda University
Loma Linda, CA 92350
U.S.A

Phone:(909) 558-9702
Fax:(909) 558-4887
E-mail: chperry@llu.edu

Profile Photo

Research Interest

Dr. Perry’s research interests at Loma Linda University focus on nanoparticles for therapeutic applications, and surface modification of materials to impart more desirable physical properties. The projects that Dr. Perry is involved include using polymeric/metal composite nanoparticles in gene therapy and as a form of combinational/adjuvent treatment for pancreatic cancer.  Second, in collaboration with Dr. Jamie Milligan (University of California at San Diego) he is studying the condensation and compaction of DNA in aqueous environments. The motivation behind this research is to develop non-viral genetic therapy vehicles.

The collaboration with Dr. Hansel Fletcher (microbiology, Loma Linda University) involves pursuing the use of nanomaterials as novel treatments for chronic periodontal disease and Methicillin resistant S. aureus infections. In conjunction with the School of Dentistry (Dr. Steve Kurti) Dr. Perry is trying to develop a surface medication approaches to lengthen the life of polymeric composite dental fillings.

Selected Publications

  1. Megan S. Holden, Jason Black, Ainsely Lewis, Marie-Claire Boutrin, Elvin Walemba, Theodore S. Sabir, Danilo S. Boskovic, A. Wilson Aruni, Hansel M. Fletcher, and Christopher C. Perry. Antibacterial Activity of Partially Oxidized Ag/Au Nanoparticles against the Oral Pathogen Porphyromonas gingivalis W83. Journal of Nanomaterials 2016, Article ID 9605906, 11 pages, 2016. doi:10.1155/2016/9605906
  2. Lee, W. C.; Fang, Y.; Kler, R.; Canciani, G. E.; Draper, T. C.; Al-Abdullah, Z. T. Y.; Alfadul, S. M.; Perry, C. C.; He, H.; Chen, Q., Marangoni ring-templated vertically aligned ZnO nanotube arrays with enhanced photocatalytic hydrogen production. Materials Chemistry and Physics 2015, 149–150 (0), 12-16.
  3. Fang, Y.; Lee, W. C.; Canciani, G. E.; Draper, T. C.; Al-Bawi, Z. F.; Bedi, J. S.; Perry, C. C.; Chen, Q., Thickness control in electrophoretic deposition of WO3 nanofiber thin films for solar water splitting. Materials Science and Engineering: B 2015, 202, 39-45.
  4. Holden, M. S.; Nick, K. E.; Hall, M.; Milligan, J. R.; Chen, Q.; Perry, C. C., Synthesis and catalytic activity of pluronic stabilized silver–gold bimetallic nanoparticles. RSC Adv. 2014, 4 (94), 52279-52288.
  5. Sabir, T. S.; Rowland, L. K.; Milligan, J. R.; Yan, D.; Aruni, A. W.; Chen, Q.; Boskovic, D. S.; Kurti, R. S.; Perry, C. C., Mechanistic Investigation of Seeded Growth in Triblock Copolymer Stabilized Gold Nanoparticles. Langmuir 2013, 29 (12), 3903-3911.
  6. Bedi Jasbir, S.; Lester Daniel, W.; Fang Yuan, X.; Turner John, F. C.; Zhou, J.; Alfadul Sulaiman, M.; Perry, C.;Chen, Q., Electrospinning of poly(methyl methacrylate) nanofibers in a pump-free process. Journal of Polymer Engineering, 2013, 33, 453
  7. Lee, M.; Urata, S. M.; Aguilera, J. A.; Perry, C. C.; Milligan, J. R., Modeling the Influence of Histone Proteins on the Sensitivity of DNA to Ionizing Radiation. Radiat. Res. 2012, 177 (2), 152-163.
  8. Do, T.; Tang, V.; Konigsfeld, K.; Aguilera, J.; Perry, C.; Milligan, J., Damage clusters after gamma irradiation of a nanoparticulate plasmid DNA peptide condensate. Radiat. Environ. Biophys. 2012, 51 (1), 43-52.
  9. Sabir, T. S.; Yan, D.; Milligan, J. R.; Aruni, A. W.; Nick, K. E.; Ramon, R. H.; Hughes, J. A.; Chen, Q.; Kurti, R. S.; Perry, C. C., Kinetics of Gold Nanoparticle Formation Facilitated by Triblock Copolymers. J. Phys. Chem. C 2012, 116 (7), 4431-4441.
  10. Perry, C.; Urata, S.; Lee, M.; Aguilera, J.; Milligan, J., Radioprotective effects produced by the condensation of plasmid DNA with avidin and biotinylated gold nanoparticles. Radiat. Environ. Biophys., 2012 (online first) DOI: 10.1007/S00411-012-0429-6 pp. 1-12.
  11. Perry, C. C.; Tang, V. J.; Konigsfeld, K. M.; Aguilera, J. A.; Milligan, J. R., Use of a Coumarin-Labeled Hexa-Arginine Peptide as a Fluorescent Hydroxyl Radical Probe in a Nanoparticulate Plasmid DNA Condensate. J. Phys. Chem. B 2011, 115 (32), 9889-9897.
  12. Perry, C. C.; Sabir, T. S.; Livingston, W. J.; Milligan, J. R.; Chen, Q.; Maskiewicz, V.; Boskovic, D. S., Fluorescence of commercial Pluronic F127 samples: Temperature-dependent micellization. J. Colloid Interface Sci. 2011, 354 (2), 662-669.
  13. Do, T. T.; Tang, V. J.; Aguilera, J. A.; Perry, C. C.; Milligan, J. R., Characterization of a Lipophilic Plasmid DNA Condensate Formed with a Cationic Peptide Fatty Acid Conjugate. Biomacromolecules 2011, 12 (5), 1731-1737.
  14. Tsoi, M.; Do, T. T.; Tang, V.; Aguilera, J. A.; Perry, C. C.; Milligan, J. R., Characterization of condensed plasmid DNA models for studying the direct effect of ionizing radiation. Biophys. Chem. 2010, 147 (3), 104-110.
  15. Al-Abdullah, Z. T. Y.; Yuyoung, S.; Rantej, K.; Perry, C. C.; Wuzong, Z.; Qiao, C., The influence of hydroxide on the initial stages of anodic growth of TiO2 nanotubular arrays. Nanotechnology 2010, 21 (50), 505601.
  16. Tsoi, M.; Do, T. T.; Tang, V.; Aguilera, J. A.; Perry, C. C.; Milligan, J. R., Characterization of condensed plasmid DNA models for studying the direct effect of ionizing radiation. Biophys. Chem. 2010, 147 (3), 104-110.
  17. Osbourne, D. O.; Aruni, W.; Roy, F.; Perry, C.; Sandberg, L.; Muthiah, A.; Fletcher, H. M., Role of vimA in cell surface biogenesis in Porphyromonas gingivalis. Microbiology 2010, 156 (7), 2180-2193.
  18. Rogstad, D. K.; Herring, J. L.; Theruvathu, J. A.; Burdzy, A.; Perry, C. C.; Neidigh, J. W.; Sowers, L. C., Chemical Decomposition of 5-Aza-2′-deoxycytidine (Decitabine): Kinetic Analyses and Identification of Products by NMR, HPLC, and Mass Spectrometry. Chem. Res. Toxicol. 2009, 22 (6), 1194-1204.
  19. Perry, C. C.; Weatherly, M.; Beale, T.; Randriamahefa, A., Atomic force microscopy study of the antimicrobial activity of aqueous garlic versus ampicillin against Escherichia coli and Staphylococcus aureus. J. Sci. Food Agric. 2009, 89 (6), 958-964.