A Seventh-day Adventist Organization

Maria Filippova, PhD

Assistant Research Professor

Basic Sciences
Division of Microbiology
School of Medicine
Loma Linda University
Loma Linda, CA 92350
U.S.A

Phone:(909) 558-1000 Ext. 81380
Fax:(909) 558-0177
E-mail:mfilippova@llu.edu

Profile Photo

Research Interest

Viral oncogenes-induced cancerogenesis and ways to inhibit it, mechanisms of modulation of epithelial differentiation by human papillomavirus (HPV) oncogenes, modulation of host defense by HPV oncogens.

Selected Publications

  1. Tungteakkhun, S. S., M. Filippova, N. Fodor and P. J. Duerksen-Hughes.  The Full Length Isoform of HPV 16 E6 and its Splice Variant E6* Bind to Different Sites on Procaspase 8 DED.  J. Virol. 84:1453-1463, 2010.  PMID:  19906919
  2. Filippova, M., V. A. Filippov, M. Kagoda, T. Garnett, N. Fodor and P. J. Duerksen-Hughes.  Complexes of Human Papillomavirus 16 E6 Proteins Form Pseudo-DISC Structures During TNF-Medicated Apoptosis.  J. Virol83:210-227, 2009.  PMID:  18842714
  3. Tungteakkhun, S., M. Filippova, J. W. Neidigh, N. Fodor and P. J. Duerksen-Hughes.  The Interaction Between HPV 16 E6 and FADD is Mediated by a Novel E6 Binding Domain.  J. Virol.  82:9600-9614, 2008.  PMID:  18632871
  4. Filippov, V., E. L. Schmidt, M. Filippova and P. J. Duerksen-Hughes. Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes.  Gene420:34-41, 2008.  PMID:  18571879
  5. Haynes, T.-A S., P. J. Duerksen-Hughes, M. Filippova, V. Filippov and K. Zhang.  C(18) Ceramide Analysis in Mammalian Cells Employing Reversed-Phase High Performance Liquid Chromatography Tandem Mass Spectrometry.  Analytical Biochemistry378:80-86, 2008.  PMID:  18423390
  6. Filippov, V., M. Filippova and P. J. Duerksen-Hughes.  The Early Response to DNA Damage Can Lead to Activation of Alternative Splicing Activity Resulting in CD44 Splice Pattern Changes.   Cancer Research67:7621-7630, 2007.  PMID:  17699766
  7. Garnett, T. O., M. Filippova and P. J. Duerksen-Hughes.  Bid is Cleaved Upstream of Caspase-8 Activation During TRAIL-Mediated Apoptosis in Human Osteosarcoma Cells.  Apoptosis12:1299-1315, 2007.   PMID:  17431792
  8. Filippova, M., M. M. Johnson, M. Bautista, V. Filippov, N. Fodor, S. S. Tungteakkhun, K. Williams and P. J. Duerksen-Hughes.  The Large and Small Isoforms of HPV 16 E6 Bind to and Differentially Affect Procaspase 8 Stability and Activity.  J. Virology.  81:4116-4129, 2007.  PMID:  17267478
  9. Garnett, T., M. Filippova, and P. J. Duerksen-Hughes.  Accelerated Degradation of FADD and Pro-Caspase 8 in Cells Expressing Human Papillomavirus 16 E6 Impairs TRAIL-Mediated Apoptosis.  Cell Death and Differentiation13:1915-1926, 2006.  PMID:  16528366
  10. Filippova, M., T. A. Brown-Bryan, C. A. Casiano and P. J. Duerksen-Hughes.  The Human Papillomavirus 16 E6 Protein Can Render Cells Either Sensitive or Resistant to TNF:  Effect of Dose.  Cell Death and Differentiation. 12:1622-1635, 2005.  PMID:  15933739
  11. Filippova, M., Parkhurst, L. and P. J. Duerksen-Hughes.  HPV 16 E6 Binds to FADD and Modulates Fas-Triggered Apoptosis.  J. Biol. Chem. 279:25729-25744, 2004.  PMID:  15073179
  12. Filippova, M., H. Song, J. L. Connolly, T. S. Dermody and P. J. Duerksen‑Hughes. The Human Papillomavirus 16 E6 Protein Binds to TNF R1 and Protects Cells from TNF‑Triggered Apoptosis.  J. Biol. Chem. 277:21730-21739, 2002.  PMID:  11934887