A Seventh-day Adventist Organization

Ubaldo Soto, PhD

Assistant Research Professor

Basic Sciences
Division of Microbiology
School of Medicine
Loma Linda University
Loma Linda, CA 92350
U.S.A

Phone:(909) 558-7562
Fax:(909) 558-4035
E-mail: usoto@llu.edu

Profile Photo

Research Interest

Cell plasticity: The connection between normal and cancer stem cells

Cell plasticity is defined as the cell capability to change its phenotype in response to microenvironmental signals.  Stem cells are a prototype of cells with high plasticity because their physiological role in generating a variety type of cells both during development as in tissue regeneration.

Interestingly, most human tumors contain a minor subpopulation of malignant cells with stem cells characteristics and high plasticity as well. Those cells are known as cancer stem cells (CSC) or tumor initiating cells because their strong capability to originate and support tumors.

My lab is exploring the interconnection between normal and cancer stem cells. We are using human induced pluripotent stem cells (iPSC) and cancer stem cells to explore the level of plasticity existing at those cells types. By manipulating in vitro the microenvironment of those cells we are studying a potential connection between iPSC and CSC.

I am member of the University of  California Riverside (UCR) - Stem Cell Center and of the Inland Empire Stem Cell Consortium.

Selected Publications

  1. Brantley E, Callero MA, Berardi DE, Campbell P, Rowland L, Zylstra D, Amis L, Yee M, Simian M, Todaro L, Loaiza-Perez A, and Soto U (2016) AhR ligand Aminoflavone inhibits α6-integrin expression and breast cancer sphere-initiating capacity. Cancer Lett. 376:53-61.
  2. Williams VM, Filippova M, Soto U, and Duerksen-Hughes PJ. (2011) HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress. Future Virol. 6:45-57.
  3. Lao VV, Herring JL, Kim C H, Darwanto A, Soto U and Sowers L (2009) Incorporation of 5-Chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns. Carcinogenesis 30:886-893.
  4. Mc Lean L, Soto U, Agama K, Francis J, Jimenez R, Pommier Y, Sowers L and Brantley E. (2008) Aminoflavone induces oxidative DNA damage and oxidative species-mediated apoptosis in breast cancer cells. Int.J.Cancer 122:1665-1674.
  5. van Riggelen J, Buchwalter G, Soto U, De-Castro Arce J, Zur Hausen H, Wasylyk B and Rösl F.( 2005) Loss of Net as repressor leads to constitutive increased c-fos transcription in cervical cancer cells. J. Biol. Chem. 280:3286-3294.
  6. De Castro-Arce, J., Soto, U., van Riggelen, J., Schwarz, E., zur Hausen, H. and Rösl, F. (2004) Ectopic expression of non-liganded RAR-{beta} abrogates AP-1 activity by selective degradation of c-Jun in cervical carcinoma cells. J Biol Chem. 279: 45408-45416.
  7. Finzer, P., Krueger, A., Stöhr, M., Brenner, D., Soto, U., Kuntzen, C., Krammer, P.H. and Rösl, F. (2004) HDAC-inhibitors trigger type II apoptosis in HPV-positive cells via induction of the E2F-p73 pathway. Oncogene 23:4807-17.
  8. Finzer, P., Ventz, R., Kuntzen, C., Seibert, N., Soto, U. and Rösl, F. (2002) Growth arrest of HPV-positive cells after histone deacetylase inhibition is independent of E6/E7 oncogene expression. Virology 304: 265-273
  9. Hergenhahn, M., Soto, U., Weninger, A., Polack, A., Hsu, C-H., Cheng, A-L. and Rösl, F. (2002) The chemopreventive compound curcumin is an efficient inhibitor of Epstein-Barr virus BZLF-1 transcription in Raji DR-Luc cells. Mol. Car. 33:137-145.
  10. Bachmann, A., Hanke, B., Zawatzky, R., Soto, U., van Riggelen, J., zur Hausen, H. and Rösl F. (2001) Disturbance of tumor necrosis factor alpha-mediated beta interferon signalling in cervical carcinoma cells. J. Virol. 76:280-291.
  11. Finzer, P., Kuntzen, C., Soto, U., zur Hausen, H. and Rösl, F. (2001) Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression. Oncogene 20:4768-4776.
  12. Finzer, P., Soto, U., Delius, H., Patzelt, A., Coy, J.F., Pustka, A.,  zur Hausen, H. and Rösl, F. (2000) Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: The role of the chromatin structure and AP-1 composition. Oncogene 19: 3235-3244.
  13. Soto, U., Denk, C., Finzer, P., Hutter, K.J., zur Hausen, H. and Rösl, F. (2000) Genetic complementation to non-tumorigenicity in cervical carcinoma cells correlates with alterations in AP-1 composition. Int. J. Cancer 86: 811-817.
  14. Soto, U., Das, B.C., Lengert, M., Finzer, P., zur Hausen, H. and Rösl, F. (1999) Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-α mediated repression of viral transcription and modification of the AP-1 transcription complex. Oncogene 18: 3187-3198.