A Seventh-day Adventist Organization

John Buchholz, PhD

Professor & Vice Chair

Division of Pharmacology
School of Medicine
Loma Linda University
Loma Linda, CA 92350
U.S.A

Phone: (909) 558-7026
Fax: (909) 558-0119
E-mail: jbuchholz@llu.edu

Profile Photo

Research Interest

Cardiovascular and neuropharmacology with a focus in autonomic regulation of  homeostasis. In particular we engage in research investigating the underlying mechanisms of modulation of cerebral blood flow via sympathetic neuronal input arising from the superior cervical ganglion.

Selected Publications

  1. Lawrence J., Chen M., Xiao D., Zhang H., Buchholz J.N. and Zhang L.: Fetal Nicotine Exposure Causes PKCe Gene Repression by Promoter Methylation in the Heart. Circ Res. 89: 89-97, 2011.
  2. Charles, SM., Zhang L., Cipolla MJ., Buchholz, JN. And Pearce, WJ.: The roles of cytosolic Ca2+ concentration and myofilament Ca2+ sensitization in Age-dependent cerebrovascular myogenic tone. Am. J. Physiol. Heart and Circ Physiol. 299(4):H1034-44, 2010.
  3. Goyal, R., Angermann, J.E. Ostrovskaya O., Buchholz, J.N. and Wilson S.M. Enhanced capacitative calcium entry and sarcoplasmic-reticulum calcium storage capacity with aging advanced age in murine mesenteric arterial smooth muscle cells. Exp. Gerontology, 44(3): 201-207, 2009.
  4. Behringer, E.K., Leite,L.D., Buchholz, N.E., Keeney, M.G., Pearce, W.J., Vanterpool, C.K., Wilson, S.M. and Buchholz, J.N. Development and Long-Term Hypoxia Alters Calcium-Induced Calcium Release in Sheep Cerebrovascular Sympathetic Neurons. J. Appl. Physiol. 107: 1223-1234, 2009.
  5. Behringer E, Vanterpool, C.K., Pearce, W.J., Wilson S.M. and Buchholz J.N. Advancing age alters the contribution of calcium release from smooth endoplasmic reticulum stores in superior cervical ganglion cells. J. Gerontol. Biolog. Sci. Med. Sci , 64A(1): 34-44, 2009.
  6. Buchholz J.N. Behringer E., Pearce, W.J. and Vanterpool, C.K. Age-dependent changes in Ca2+ homeostasis in peripheral neurones: Implications for changes in function. Invited Review Special Issue on Aging Cell. 6:285-296, 2007.
  7. Vanterpool, C.K., Vanterpool, E., Pearce, W.J. and BuchholzJ.N. Advancing age selectively alters the expression of the major ryanodine receptor isoforms in adult rat superior cervical ganglia. J. Appl Physiol. 101(2): 392-400, 2006.
  8. Xiao, D., Buchholz, J.N., Zhang L. Pregnancy attenuates uterine artery pressure dependent vascular tone: role of PKC/ERK pathway. Am. J.  Physiol. Heart and Circ. Physiol. 290: H2337-H2343, 2006.
  9. Zhao, H, Austin, R.R., Christian, S.L., Buchholz, J.N. and Drew, K.L. Decreased NR1 phosphorylation and decreased NMDAR function in hibernating Arctic ground squirrels J. Neurosci. Res. 84: 291-298, 2006.
  10. Charles, S.M.,  Zhang, L., Longo, L.D., Buchholz, J.N. and Pearce, W.J Maturation alters calcium dependent sensitivity of pressure dependent cerebrovascular myogenic tone, Am. J. Physiol. Reg. Comp. Physiol. 293: R737-R744, 2007.
  11. Vanterpool, C.K., Pearce, W.J. and  Buchholz, J.N. Advancing age alters rapid and spontaneous refilling of caffeine sensitive calcium stores in sympathetic superior cervical ganglion cells. J. Appl. Physiology, 99:963-971, 2005.
  12. Geary, G.G.  and  Buchholz, J.N.: Effects of aging on intrinsic tone and [Ca2+]i in rat cerebral arteries. J. Appl. Physiol. 95:1746-1754, 2003.
  13. Geary, G. Buchholz, J. and Pearce W.J. Maturation depresses mouse cerebrovascular tone through endothelium-dependent mechanisms.  Am. J. Physiol. Reg. Comp. Physiol. 284:R734-741,2003.
  14. Mbaku, E., Zhang, L., Duckles, S.P. and Buchholz, J. High altitude hypoxia alters function of nitric oxide synthase nerves and nNOS levels in fetal and adult sheep cerebral arteries.  J. Applied Physiol. 94:724-732, 2003.
  15. Bishai, J.M., Meulenaar, R., Penninga, L., Nijland, R., Gheroghe, C.P., Ueno, N., Zhao, Y., Buchholz, J.N., Zhang, L. and Longo, L.D.:  Pre-and post synaptic a2-adrenergic receptors in fetal and adult ovine cerebral arteries.  Am. J. Physiol. 282:R1654-R1662, 2002.
  16. Pottorf, W.J., Duckles, S.P. and Buchholz, J.: Calcium buffering and aging in sympathetic neurons.  J. Auto. Nervous. Sys 96: 2-7, 2002.
  17. Pottorf, W.J., De Leon, D.D., Hessinger, D. A., and Buchholz, J.: Effect of Aging on Function of SERCA Mediated Calcium Uptake and Expression of SERCA3 in Rat Cerebral Cortex.  Brain Res. 914 (1,2): 57-65, 2001.
  18. Pottorf, W.J., Duckles, S.P. and Buchholz, J.: SERCA function declines with advancing age in adrenergic nerves from superior cervical ganglion.  J. Autonom. Pharmacol. 20: 281-290, 2001.
  19. Buchholz, J. and Duckles, S.P.:  Chronic hypoxia alters prejunctional modulation of sympathetic nerves by a2-autoreceptors in fetal and adult middle cerebral arteries.  Am. J. Physiol. 281:R926-R934, 2001.
  20. Pottorf, W.J., Duckles, S.P. and Buchholz, J.: Mechanisms of calcium buffering and aging in adrenergic neurons: Testing the limits of homeostasis.  J. Autonom. Pharmacol.20: 63-75, 2000