Emeritus Professor

Basic Sciences
Division of Biomedical Engineering Sciences
Division of Microbiology
School of Medicine
Loma Linda University
Loma Linda, CA 92350
U.S.A

Phone:(909) 558-8361
Fax:(909) 558-0825
E-mail: dgridley@llu.edu

Profile Photo

Research Interest

  • Radiosensitization of tumors in pre-clinical models
  • Radioprotection of normal tissues in pre-clinical models
  • Radiotherapy/immunotherapy of cancer
  • Markers that predict human radiosensitivity                                        
  • Biological effects of proton radiation and spaceflight conditions

Selected Publications

  1. Mehrotra, S., Pecaut, M.J., Freeman, T.L., Crapo, J.D., Rizvi, A., Luo-Owen, X., Slater, J.M., and Gridley, D.S. Analysis of a metalloporphyrin antioxidant mimetic (MnTE-2-PyP) as a radiomitigator: prostate tumor and immune status. Technol. Cancer Res. Treat. In press, 2012.
  2. Mao, X.W., Crapo, J.D., and Gridley, D.S. Mitochondrial oxidative stress-induced apoptosis and radioprotection in proton-irradiated rat retina. Radiat. Res. In press, 2012.
  3. Luo-Owen, X., Pecaut, M.J., Rizvi, A., and Gridley, D.S. Low-dose total-body gamma-irradiation modulates immune response to acute proton radiation. Radiat. Res. 177(3):251-264, 2012.
  4. Gridley, D.S., Freeman, T.L., Makinde, A.Y., Wroe, A.J., Luo-Owen, X., Tian, J., Mao, X.W., Kennedy, A.R., Slater, J.M., and Pecaut, M.J. Comparison of proton and electron radiation effects on biological responses in liver, spleen and blood. Int. J. Radiat. Biol. 87(12):1173-1181, 2011.
  5. Tian, J., Zhao, W.L., Tian, S., Slater, J.M., Deng, Z., and Gridley, D.S. Expression of genes involved in mouse lung cell differentiation/regulation after acute exposure to photons and protons with and without low dose pre-irradiation. Radiat. Res. 176(5):553-564, 2011.
  6. Gridley, D.S., Pecaut, M.J., Green, L.M., Sanchez, M.C., and Kadhim, M.A. Strain-related differences and radiation quality effects on mouse leukocytes: gamma-rays and protons (with and without aluminum shielding). In Vivo. 25(6):871-880, 2011.
  7. Dicello, J.F., Slater, J.D., Slater, J.M., Peterson, F.F., Grove, R.I., Gridley D.S., and Schulte, R.W. Epidemiological analysis of patients with prostate cancer treated with proton beams at LLUMC. Radiat. Meas. 46(2011):1940-1943, 2011. Available at: http://sciencedirect.com/science/journal/13504487
  8. Gridley, D.S. and Pecaut, M.J. Genetic background and lymphocyte populations after total-body exposure to iron ion radiation. Int. J. Radiat. Biol. 87(1):8-23, 2011.
  9. Gridley, D.S., Luo-Owen, X., Rizvi, A., Makinde, A.Y., Pecaut, M.J., Mao, X.W., and Slater, J.M. Low-dose photon and simulated solar particle event proton effects on Foxp3+ T regulatory cells and other leukocytes. Technol. Cancer Res. Treat. 9(6):637-649, 2010.
  10. Makinde, A.Y., Rizvi, A., Crapo, J.D., Pearlstein, R.D., Slater, J.M., and Gridley, D.S. A metalloporphyrin antioxidant alters cytokine responses after radiation in a prostate tumor model. Radiat. Res. 173(4):441-452, 2010.
  11. Gridley, D.S., Grover, R.S., Loredo, L.N., Wroe, A.J., and Slater, J.D. Proton beam therapy for tumors of the central nervous system. Expert Rev. Neurother. 10(2):319-330, 2010. (Invited review)
  12. Tian, J., Pecaut, M.J., Slater, J.M., and Gridley, D.S. Spaceflight modulates expression of extracellular matrix, adhesion and profibrotic molecules in mouse lung. J. Appl. Physiol. 108(1):162-171, 2010.
  13. Gridley, D.S., Rizvi, A., Luo-Owen, X., Makinde, A.Y., and Pecaut, M.J. Low dose, low dose rate photon radiation modifies leukocyte distribution and gene expression in CD4+ T cells. J. Radiat. Res. 50(2):139-150, 2009.
  14. Tian, J., Pecaut, M.J., Coutrakon, G.B., Slater, J.M., and Gridley, D.S. Response of extracellular matrix regulators in mouse lung after exposure to photons, protons and simulated solar particle event protons. Radiat. Res. 172(1):30-41, 2009.
  15. Gridley, D.S., Pecaut, M.J., Rizvi, A., Coutrakon, G.B., Luo-Owen, X., Makinde, A.Y., and Slater, J.M. Low-dose, low-dose-rate proton radiation modulates CD4+ T cell gene expression. Int. J. Radiat. Biol. 85(3):250-261, 2009.
  16. Gridley, D.S., Slater, J.M., Luo-Owen, X., Rizvi, A., Chapes, S.K., Stodieck. L.S., Ferguson, V.L., and Pecaut, M.J. Spaceflight effects on T lymphocyte distribution, function and gene expression. J. Appl. Physiol. 106(1):194-202, 2009.
  17. Gridley, D.S., Coutrakon, G.B., Rizvi, A., Bayeta, E.J.M., Luo-Owen, X., Makinde, A.Y., Baqai, F., Koss, P., Slater, J.M., and Pecaut, M.J.  Low dose photons modify liver response to simulated solar particle event protons. Radiat. Res. 169:280-287, 2008.
  18. Gridley, D.S., Rizvi, A., Luo-Owen, X., Makinde, A.Y., Coutrakon, G.B., Koss, P., Slater, J.M., and Pecaut, M.J. Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons. In Vivo. 22:159-169, 2008.
  19. Gridley, D.S., Miller, G.M., and Pecaut, M.J. Radiation and primary response to lipopolysaccharide: bone marrow-derived cells and susceptible organs. In Vivo.  21(3):453-461, 2007.
  20. Gridley, D.S., Bonnet, R.B., Bush, D.A., Franke, C., Cheek, G.A., Slater, J.D., and Slater, J.M. Time course of serum cytokines in patients receiving proton or combined photon/proton beam radiation for resectable but medically inoperable non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 60(3):759-766, 2004.