Associate Professor

Basic Sciences
Division of Pharmacology
School of Medicine
Loma Linda University
Loma Linda, CA 92350

Phone: (909) 651-5334
Fax: (909) 558-0119

Erik Beringer-2

Research Interests:

Vascular signatures of aging and Alzheimer's disease.

Selected Publications:

  1. Hakim MA, Pires PW, Behringer EJ. Isolation and functional resolution of arteriolar endothelium of mouse brain parenchyma. J Vis Exp. e63463, 2022. DOI:10.3791/63463;
  2. Chum PP, Hakim MA, Behringer EJ. Cerebrovascular microRNA expression profile during early development of Alzheimer’s disease in a mouse model. J Alzheimer’s Dis. 85(1):91-113, 2022. PMID: 34776451; DOI: 10.3233/JAD-215223
  3. Hakim MA and Behringer EJ. Methyl-beta-cyclodextrin restores KIR channel function in brain endothelium of female Alzheimer’s disease mice. J Alzheimer’s Dis Rep. 5(1): 693-703, 2021. doi: 10.3233/ADR-210016
  4. Hakim MA and Behringer EJ. Development of Alzheimer's disease progressively alters sex-dependent KCa and sex-independent KIR channel function in cerebrovascular endothelium. J Alzheimer’s Dis., 76(4):1423-1442, 2020. DOI: 10.3233/JAD-200085.
  5. Hakim MA, Nye-Chum P, Buchholz JN, Behringer EJ. Aging alters cerebrovascular endothelial GPCR and K+ channel function: Divergent role of biological sex. J Gerontol A Biol Sci Med Sci. 75(11):2064-2073, 2020. DOI:10.1093/gerona/glz275.
  6. Stoll S, Xi J, Ma B, Leimena C, Behringer EJ, Qin G, Qiu H. The valosin-containing protein protects the heart against pathological Ca2+ overload by modulating Ca2+ uptake proteins. Toxicol Sci. pii: kfz164, 2019. DOI: 10.1093/toxsci/kfz164.
  7. Behringer EJ and Hakim MA. Functional Interaction among KCa and TRP Channels for Cardiovascular Physiology: Modern Perspectives on Aging and Chronic Disease. Int. J. Mol. Sci. 20: 1380, 2019. DOI:10.3390/ijms20061380.
  8. Hakim MA and Behringer EJ. Simultaneous Measurements of Intracellular Calcium and Membrane Potential in Freshly Isolated and Intact Mouse Cerebral Endothelium. J Vis Exp. Jan 20: 143, 2019. DOI: 10.3791/58832.
  9. Hakim MA, Buchholz JN, Behringer EJ. Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: differential roles of G-Protein coupled receptors and K+ channels. Pharmacol Res Perspect. 6(2): e00391, 2018.
  10. Kapela A, Behringer EJ, Segal SS and Tsoukias NM. Biophysical properties of microvascular endothelium: Requirements for initiating and conducting electrical signals. Microcirculation. 25(2): 1-15, 2018.
  11. Behringer EJ*, Scallan JP*, Jafarnejad M, Castorena-Gonzalez JA, Zawieja SD, Moore JE Jr, Davis MJ, Segal SS. Calcium and electrical dynamics in lymphatic endothelium. J Physiol. 595(24): 7347-7368, 2017. *Equal contribution.
  12. Behringer EJ and Segal SS. Impact of aging on calcium signaling and membrane potential in endothelium of resistance arteries: A role for mitochondria. J Gerontol A Biol Sci Med Sci. 72(12): 1627-1637, 2017.
  13. Behringer EJ. Calcium and electrical signaling in arterial endothelial tubes: New insights into cellular physiology and cardiovascular function. Microcirculation. 24(3): 1-12, 2017.
  14. Behringer EJ and Segal SS. Membrane potential governs calcium influx into microvascular endothelium: Integral role for muscarinic receptor activation. J Physiol. 593(20): 4531-48, 2015.
  15. Socha MJ, Boerman EM, Behringer EJ, Shaw RL, Domeier TL, and Segal SS. Advanced age protects microvascular endothelium from aberrant Ca2+ influx and cell death induced by hydrogen peroxide. J Physiol. 593(9): 2155-69, 2015.
  16. Behringer EJ, Shaw RL, Westcott EB, Socha MJ, and Segal SS. Aging impairs electrical conduction along endothelium of resistance arteries through enhanced Ca2+-activated K+ channels activation. Arterioscler Thromb Vasc Biol. 33(8): 1892-1901, 2013.
  17. Behringer EJ and Segal SS. Spreading the signal for vasodilatation: Implications for skeletal muscle blood flow control and the effects of aging. J Physiol. 590 (Pt 24): 6277-84, 2012.
  18. Socha MJ, Domeier TL, Behringer EJ, Segal SS. Coordination of intercellular Ca2+ signaling in endothelial cell tubes of resistance arteries. Microcirculation. 19(8): 757-70, 2012.
  19. Behringer EJ and Segal SS. Tuning electrical conduction along endothelial cell tubes through Ca2+-activated K+ channels. Circ Res. 110(10): 1311-1321, 2012.
  20. Behringer EJ, Socha MJ, Polo-Parada L, Segal SS. Electrical conduction along endothelial cell tubes from mouse feed arteries: confounding actions of glycyrrhetinic acid derivatives. Br J Pharmacol. 166(2): 774-787, 2012.
  21. Socha MJ*, Behringer EJ*, Segal SS. Calcium and electrical signaling along endothelium of the resistance vasculature. Basic Clin Pharmacol Toxicol. 110(1): 80-86, 2012. *Equal contribution
  22. Behringer EJ, Leite LD, Buchholz NE, Keeney M, Pearce WJ, Vanterpool CK, Wilson SM and Buchholz JN. Maturation and long-term hypoxia alters calcium-induced calcium release in sheep cerebrovascular sympathetic neurons.  J Appl Physiol. 107(4): 1223-1234, 2009.
  23. Behringer EJ, Vanterpool CK, Pearce WJ, Wilson SM and Buchholz JN.  Advancing age alters the contribution of calcium release from smooth endoplasmic reticulum stores in superior cervical ganglion cells. J Gerontol A Biol Sci Med Sci. 64A: 34-44, 2009.
  24. Buchholz JN, Behringer EJ, Pottorf BJ, Pearce WJ and Vanterpool CK.  Age–dependent changes in Ca2+ homeostasis in peripheral neurons:  implications for changes in function.  Aging Cell. 6(3):  285-296, 2007.


Book Chapters

  1. Buchholz JN and Behringer EJ (Editors). Calcium and Signal Transduction. Physiology Series, Volume 1. Publisher, Intech Open; ISBN: 978-1-78984-249-4, 2019.
  2. Behringer EJ and Segal SS. Vascular Ion Channels in Physiology and Disease, Chapter title: Ion Channels in Control of Blood Flow: Electrical Conduction Along Endothelium of Resistance Arteries. Publisher, Springer. ISBN: 978-3319296333, 2016.
  3. Buchholz JN, Pottorf WJ, Vanterpool CK, Behringer EJ and Duckles SP. Senescence, Chapter title: Calcium Regulation in Neuronal Function with Advancing Age: Limits of Homeostasis. Publisher, In-Tech Open Access. ISBN: 978-953-308-28-6, 2012.