Division of Physiology
School of Medicine
Loma Linda University
Loma Linda, CA 92350
Phone: (909) 558-7042
Fax: (909) 558-0119
Our research focuses on regulation and function of ion channels in vascular smooth muscle and satiety/obesity. In vascular physiology, we currently use a sheep model to study the role of large-conductance potassium (BK) channels in (i) pulmonary vasodilation at birth and (ii) adult and fetal cerebral artery high-altitude acclimatization. In satiety physiology, we use en-masse cultured, monoclonal sea anemones to identify and study conserved pathways involved in satiety regulation.
Selected Vascular Physiology Publications
- Tao, Xiaoxiao, Lin, Mike T., Thorington, Glyne U., Wilson, Sean M., Longo, Lawrence D., Hessinger, David A. Long-Term Hypoxia Increases Calcium Affinity of BK Channels in Ovine Fetal and Adult Cerebral Artery Smooth Muscle. Am J Physiol, Heart Circ; manuscript no. H-005644-2014.
- Tao, Xiaoxiao, Shi, Lijun, Longo, Lawrence D., Hessinger, Lawrence D. Protein Kinase C activates BK channels in fetal, but not adult, middle cerebral arteries. Submitted to Am J Physiol, Regulatory, Integrative, Comp Physiol; manuscript no. R-00352-2014.
- Lin, Mike T, Hessinger, David A, Pearce, William J, and Longo, Lawrance D. Modulation of BK channel calcium affinity by differential phosphorylation in developing ovine basilar artery myocytes. Am J Physiol Heart Circ Physiol 291:H732-H740, 2006.
- Lin. Mike T, Longo. Lawrance D, Pearce. William J, Hessinger, David A. Ca2+-activated K+ channel associated phosphatase and kinase activities during development. Am J Physiol Heart Circ Physiol 289: H1-H12, 2005.
- Lin, Mike T., Hessinger, David A, Pearce, William J, Longo, Lawrance D. Developmental difference in the Ca2+-activated K+ (BKCa) channel activity in ovine basilar artery. Am J Physiol Heart Circ Physiol H701-H709, 2003.
Selected Satiety Physiology Publications
- Thorington, Glyne U. and Hessinger, David A. Roles of calcium in nematocyst discharge from sea anemone (Aiptasia pallida and Haliplanella luciae) tentacles. J Exp Biol, manuscript #JEXBIO/078329, accepted with revisions.
- Thorington, Glyne U, MacAuley, Virginia N., Hessinger, David A. Effects of satiation and starvation on nematocyst discharge, prey killing, and ingestion in two species of sea anemone. Biol Bull 219:122-131, 2010.
- Edwards LP, Whitter E, and DA Hessinger. Apparent membrane pore formation by Portuguese Man-of-war (Physalia physalis) venom in intact cultured cells. Toxicon 40: 1299-1305, 2002.
- Ozacmak, Haktan, Thorington, Glyne U, Fletcher, William H, Hessinger, David A. N-acetylneuraminic acid (NANA) stimulates in situ cyclic AMP production in tentacles of sea anemone (Aiptasia pallida): possible role in chemosensitization of nematocyst discharge. J Exp Biol 204: 2011-2020, 2001.
- Grotendorst, Gary R and Hessinger, David A. 1999 Purification and partial characterization of the phospholipase A2 and co-lytic factor from sea anemone (Aiptasia pallida) nematocyst venom. Toxicon 37:1779-96.
- Thorington Glyne U and Hessinger, David A. Efferent mechanisms of discharging cnidae: II. A nematocyst release response in the sea anemone tentacle. Biol Bull 195: 145-155,1998.
- Watson GM and DA Hessinger. Cnidocyte mechanoreceptors are tuned to the movements of swimming prey by chemoreceptors. Science 243: 1589:1591,1989.
- Hessinger DA and HM Lenhoff (editors). The Biology of Nematocysts. Academic Press, San Diego, CA, 600 pp., 1988.