Basic Sciences
Division of Physiology
School of Medicine
Loma Linda University
Loma Linda, CA 92350

Phone:  (909) 558-1000, Ext. 88130
Fax:  (909) 558-0119

Profile Photo

Research Interest

Exploration of fundamental biological processes and neurological mechanisms of vascular disease, studied through translational pre-clinical modeling approaches. The ultimate goal is prevention and lessening of disabilities attributed to stroke.

Selected Publications

  1. Lekic T, Klebe D, McBride DW, Manaenko A, Rolland WB, Flores JJ, Altay O, Tang J, Zhang JH. Protease-activated receptor 1 and 4 signal inhibition reduces preterm neonatal hemorrhagic brain injury. Stroke. 2015 Jun;46(6):1710-3
  2. Lekic T, Klebe D, Poblete R, Krafft PR, Rolland WB, Tang J, Zhang JH. Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network. Curr Med Chem. 2015;22(10):1214-38
  3. Flores JJ, Zhang Y, Klebe DW, Lekic T, Fu W, Zhang JH; Small molecule inhibitors in the treatment of cerebral ischemia; Expert Opin. Pharmacother.; 2014;15(5);659-80
  4. Manaenko A, Lekic T, Barnhart M, Hartman R, Zhang JH; Inhibition of transforming growth factor-β attenuates brain injury and neurological deficits in a rat model of germinal matrix hemorrhage; Stroke; 2014;45(3);828-34
  5. Klebe D, Krafft PR, Hoffmann C, Lekic T, Flores JJ, Rolland W, Zhang JH. Acute and delayed deferoxamine treatment attenuates long-term sequelae after germinal matrix hemorrhage in neonatal rats. Stroke. 2014 Aug;45(8):2475-9
  6. Lekic T, Rolland W, Manaenko A, Krafft PR, Kamper JE, Suzuki H, Hartman RE, Tang J, Zhang JH; Evaluation of the hematoma consequences, neurobehavioral profiles, and histopathology in a rat model of pontine hemorrhage; J. Neurosurg.; 2013;118(2);465-77
  7. Leitzke AS, Rolland WB, Krafft PR, Lekic T, Klebe D, Flores JJ, Van Allen NR, Applegate RL 2nd, Zhang JH; Isoflurane Post-Treatment Ameliorates GMH-Induced Brain Injury in Neonatal Rats; Stroke; 2013;44(12);3587-90
  8. Manaenko A, Lekic T, Ma Q, Zhang JH, Tang J; Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice; Crit. Care Med.; 2013;41(5);1266-75
  9. Lekic T, Manaenko A, Rolland W, Krafft PR, Peters R, Hartman RE, Altay O, Tang J, Zhang JH; Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus; Exp. Neurol.; 2012;236(1);69-78
  10. Krafft PR, Bailey EL, Lekic T, Rolland WB, Altay O, Tang J, Wardlaw JM, Zhang JH, Sudlow CL; Etiology of stroke and choice of models; Int. J. Stroke; 2012;7(5);398-406
  11. Lekic T, Rolland W, Hartman R, Kamper J, Suzuki H, Tang J, Zhang JH; Characterization of the brain injury, neurobehavioral profiles, and histopathology in a rat model of cerebellar hemorrhage; Exp. Neurol.; 2011;227(1);96-103
  12. Sherchan P, Lekic T, Suzuki H, Hasegawa Y, Rolland W, Duris K, Zhan Y, Tang J, Zhang JH; Minocycline improves functional outcomes, memory deficits, and histopathology after endovascular perforation-induced subarachnoid hemorrhage in rats; J. Neurotrauma; 2011;28(12);2503-12
  13. Zhou Y, Fathali N, Lekic T, Ostrowski RP, Chen C, Martin RD, Tang J, Zhang JH; Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway; Stroke; 2011;42(2);439-44
  14. Lekic T, Krafft PR, Coats JS, Obenaus A, Tang J, Zhang JH; Infratentorial Strokes for Posterior Circulation Folks: Clinical Correlations for Current Translational Therapeutics; Transl. Stroke Res.; 2011;2(2);144-151
  15. Zhou Y, Lekic T, Fathali N, Ostrowski RP, Martin RD, Tang J, Zhang JH; Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway; Stroke; 2010;41(7);1521-7
  16. Fathali N, Ostrowski RP, Lekic T, Jadhav V, Tong W, Tang J, Zhang JH; Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury; Crit. Care Med.; 2010;38(2);572-8
  17. Lekic T, Hartman R, Rojas H, Manaenko A, Chen W, Ayer R, Tang J, Zhang JH; Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats; J. Neurotrauma; 2010;27(3);627-37
  18. Fathali N, Lekic T, Zhang JH, Tang J; Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats; Intensive Care Med.; 2010;36(9);1602-8
  19. Lekic T, Zhang JH; Posterior circulation stroke and animal models; Front. Biosci.; 2008;13;1827-44
  20. Sood SM, Lekic T, Jhawar H, Farrell HM Jr, Slattery CW; Reconstituted micelle formation using reduced, carboxymethylated bovine kappa-casein and human beta-casein; Protein J.; 2006;25(5);352-60