Principal Investigator

Kimberly Payne, PhD
Associate Professor & Director, Translational Research
Division of Anatomy
kpayne@llu.edu
Phone: 909-558-4300 Ext. 81363

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People


Ineavely Baez
Senior Research Assistant
idelgado@llu.edu
Phone: 909-558-4300 Ext. 81372

Research Description

I assist with all of the projects in Dr. Payne’s laboratory. I assist Dr. Payne in training students to stain cells for flow cytometry and to collect and analyze flow cytometry data. I am also in charge of collecting and processing umbilical cord blood and leukemia samples that are collected as a part of our research studies.

Selected Publications

  1. Parrish YK, Báez I, Milford T-A, Benitez A, Galloway N, Willeman-Rogerio J, Sahakian E, Kagoda M, Huang G, Hao QL, Sevilla Y, Barsky LW, Zielinska E, Price MA, Wall NR, Dovat S, and Payne KJ. (2009) IL-7 Dependence of Human B Lymphopoiesis Increases During Progression of Ontogeny from Cord Blood to Bone Marrow. J Immunol., 182(7):4255-66. PMCID: 2659466.
  2. Odumosu O, Payne K, Báez I, Jutzy J, Wall N, Langridge W. (2011) Suppression of dendritic cell activation by diabetes autoantigens linked to the cholera toxin B subunit. Immunobiology. 216(4):447-56. PMID:20956025

Olivia Francis
Graduate Student
ofrancis@llu.edu
Phone: 909-558-4300 Ext. 81372

Research Description

My project focuses on cellular mechanisms and therapies for human CRLF2 B-cell Acute Lymphoblastic Leukemia (B-ALL). The goal of this study is to identify the role of the cytokines TSLP and IL-7 in the development/maintenance of human CRLF2 positive B-ALL and to identify therapeutic candidates that can be used to treat patients with the disease.

Publications

O. L. Francis, J.L. Payne, R. Su and K.J. Payne. World (2011). Regulator of Myeloid Differentiation and Function: The Secret Life of Ikaros. J Biol Chem, 2(6): 199-125


Terry-Ann Milford
Graduate Student
tmilford@llu.edu
Phone: 909-558-4300 Ext. 81369

Research Description

Normal B cell development is a guided interplay between hematopoietic stem cells, cytokine-receptor signals and transcription factors. Thymic stromal lymphopoietin (TSLP) is one such cytokine and in the mouse, it has been shown to impact B cell development, although its exact contribution is unclear. Less is known about its function in normal human B cell development, although overexpression of one of its receptor components has recently been implicated in pre-B ALL, the most common childhood malignancy. My project is focused on understanding the role of TSLP in normal human neonatal and adult B cell development.

Publications

  1. Parrish YK, Báez I, Milford T-A, Benitez A, Galloway N, Willeman-Rogerio J, Sahakian E, Kagoda M, Huang G, Hao QL, Sevilla Y, Barsky LW, Zielinska E, Price MA, Wall NR, Dovat S, and Payne KJ. (2009) IL-7 Dependence of Human B Lymphopoiesis Increases During Progression of Ontogeny from Cord Blood to Bone Marrow. J Immunol., 182(7):4255-66. PMCID: 2659466.
  2. K. J. Payne, L. A. Cylde, A. J. Weldon, T. A. Milford, and S. M. Yellon. Biology of Reproduction. (2012) Residency and Activation of Myeloid Cells During Remodeling of the Prepartum Murine Cervix. Submitted.

Abby Weldon
Graduate Student
aweldon@llu.edu
Phone: 909-558-4300 Ext. 81372

Research Description

Tumor Necrosis Factor Superfamily (TNFSF) members APRIL and BAFF have been implicated in B cell mediated autoimmune pathology. Elevated levels of BAFF and/or APRIL may contribute to the breakdown of negative selection mechanisms. Serum levels of APRIL and BAFF are elevated in patients with SLE and RA and surface forms of these proteins have been detected on normal and/or malignant B lineage cells. Using flow cytometry we found surface forms of APRIL and BAFF on peripheral blood B cells from SLE and RA patients. The aims of my project is to compare surface expression of APRIL and BAFF and their receptors on B cells from SLE and RA patients to normal B cells and to elucidate their roles in B cell-mediated autoimmunity.

Publications

  1. E. E. Vomhof-Dekrey, A. R. Sandy, J. J. Failing, R. J. Hermann, S. A. Hoselton, J. M. Schuh; A. J. Weldon, K. J. Payne,  G. Dorsam.  Peptides. 32, 2058-2066 (2011) Radical Reversal of Vasoactive Intestinal Peptide Receptors During Early Lymphopoiesis.
  2. K. J. Payne, L. A. Cylde, A. J. Weldon, T. A. Milford, and S. M. Yellon. Biology of Reproduction. (2012) Residency and Activation of Myeloid Cells During Remodeling of the Prepartum Murine Cervix. Submitted.