A Seventh-day Adventist Organization

Aldo Bruccoleri, PhD

Adjunct Research Professor

University of Calgary

E-mail:bruccole@ucalgary.ca

Research Interest

Supramolecular biomedical research

Supramolecular chemistry plays an integral role in the field of molecular nanotechnology. Dr. Bruccoleri has been studying natural and synthetic supramolecular chemical complexes for over fifteen years, and he has applied this relatively new technology with success in the development of certain novel HIV-1 RT inhibitors (Bruccoleri, 2013, http://www.ncbi.nlm.nih.gov/pubmed/22938539). Dr. Bruccoleri has now extended his work towards the design of novel antioxidant neuroprotection and anticancer agents, with ongoing collaborations at the University of Calgary, and McGill University. At the heart of Dr. Bruccoleri’s research is the use of non-covalent interactions leading to desired supramolecular complexes. Unique 3-D molecular architectures may be purposefully designed for unique biomedical applications.

Selected Publications

  1. Bruccoleri, A., Langford, C.H., Chamoli, U. (2013). Humic Derived Compounds Demonstrate Antiretroviral and Antibacterial Properties, invited conference: Humic Substances & Technology (North Eastern University Boston, March 20-22).
  2. Bruccoleri, A., (Jan 2013). Positional Adaptability in the Design of Mutation-Resistant Non-Nucleoside HIV-1 RT Inhibitors: A Supramolecular Perspective, AIDS Research & Human Retroviruses: http://www.ncbi.nlm.nih.gov/pubmed/22938539
  3. Gamble, D.S., Langford, C.H., Bruccoleri, A. (2006). Use Of Humic Substances To Remediate Polluted Environments: From Theory To Practice, I. V. Perminova, K. Hatfield, N. Hertkorn (Eds.), Chemical Stoichiometry And Molecular Level Mechanisms As Support For Future Predictive Engineering Calculations, NATO Science Series, Kluwer Academic Publisher, Dordrecht, pp53-83.
  4. Ariese, F., Assema, S., Gooijer, C., Bruccoleri, A., and Langford , C.H., Comparison of Laurentian Fulvic Acid Luminescence with that of the Hydroquinone/Quinone Model System: Evidence from Low Temperature Fluorescence Studies and EPR Spectroscopy, Aquatic Sciences, 66, 86-94, (2004).
  5. Bruccoleri, A., Langford, C.H., Molecular Modeling of Humic Structures.(2001), In E. A. Ghabbour and G. Davies, Eds. Humic Substances; Structures, Models, And Functions, Royal Society of Chemistry, Special Publication 273, Cambridge. 193–208.
  6. Bruccoleri, A., Langford, C.H., Computational Modeling of Humic Structures: A View From the Edge of the Cliff, In E.A. Ghabbour and G. Davies, Eds., Humic Substances Seminar V,  Book of Abs.(invited presentations), Northeastern University, Boston, MA,  2001.
  7. Gamble, D.S., Lindsay E., Bruccoleri, A., Langford C.H., Leyes G.A., Chlorothalonil and Its 4-Hydroxy Derivative In Simple Quartz Sand Soils: A Comparison Of Sorption Processes, Environ Science & Technology, (2001), 35(11):2375-80. (Ricerca PDF project
  8. Gamble, D.S., Lindsay E., Bruccoleri, A., Langford C.H., Leyes G.A., Chlorothalonil and its 4-Hydroxy Derivative in Quartz Sand Soils, Canadian Society for Chemistry (CSC), Chemistry in Life Sciences, Book of Abs., 84, No. 60, Montreal, Quebec, (2001). (Ricerca PDF project)
  9. Bruccoleri, A., Langford, C.H., Lepore, G.,  Primary Photochemical and Photophysical Processes In Laurentian And Mossy Point Fulvic Acid: Photochemistry, Photosensitization, In E.A. Ghabbour and G. Davies, Eds., Humic Substances Seminar IV,  Book of Abs.(invited presentations), Northeastern University, Boston, MA, (2000).
  10. Bruccoleri, A., Langford, C.H., Sorenson, B., Modeling Humic Substance Structures, Canadian Society for Chemistry (CSC), Chemistry:  Special invited presentations book of Abs., 83, No. 166, Calgary, Alberta, (2000).
  11. Gamble, D.S., Lindsay E., Bruccoleri, A., Langford C.H., Leyes G.A., Chlorothalonil in a Quartz Sand Soil: Speciation and Kinetics, Environmental Science and Technology, Vol. 34, No. 1, 2000, pp 120-125. (Ricerca PDF project)
  12. Gamble, D.S., Lindsay E., Bruccoleri, A., Langford C.H., Leyes G.A., 2,4,6 –Trichloro –4- Hydroxyisophthalonitrile in Sandy Soils: Sorption Stoichiometry In Support Of Mechanism Studies, Canadian Society for Chemistry (CSC), Chemistry: Challenges for a New Century, Book of Abs., 83, No. 166, Calgary, Alberta, (2000). (Ricerca PDF project)
  13. Gamble, D.S., Lindsay E., Bruccoleri, A., Langford C.H., Leyes G.A., Chlorothalonil in a Quartz Sand Soil: Wetting Effects on Sorption Capacity and Bound Residue, Environmental Science and Technology, Vol. 34, No. 1, (2000), pp 125-130.  (Ricerca PDF project)
  14. Bruccoleri, A., Langford, C.H.,  Photochemistry of Well Characterized Fulvic Acids, Canadian Society for Chemistry (CSC), Pacifichem, International Chemical Congress of Pacific Basin Societies (invited presentations), Book of Abs., (2000), Honolulu, USA.
  15. Bruccoleri, A., Langford, C.H., Photophysics and Photochemistry of Two Well Characterized Fulvic Acids, Invited presentations: Book of Abstracts of the 10th International Meeting of the International Humic Substance Society, IHSS, (2000), Toulouse, France.
  16. Bruccoleri, A., Langford, C.H., Primary Photophysics and Photochemistry of Fulvic Acid, Invited presentations, book of abstracts of Technical Papers of the Annual Meeting of the Canadian Society of Soil Science, Charlottetown, (1999).
  17. Bruccoleri, A., Langford, C.H., Time Resolved Photoacoustic Spectroscopy and Fulvic Acid Quantum Yields, Special Publication of Invited Presentations of the 12th International Conference on Photochemical Conversion and Storage of Solar Energy,  (IPS 12) Germany, Berlin, Tributsch, H., Willig, F. (Hrg.), Abstract, S. 3W15, (1998).
  18. Bruccoleri, A.G., Langford, C.H.,  Proc. the 8th Annual Society of Environmental Toxicology and Chemistry (SETAC), Bordeaux, France, (1998), 8th SETAC Europe Annual Congress, Interfaces in Environmental Chemistry and Toxicology: From the Global to the Molecular Level; Photochemistry and Photophysics of a Well Characterized Fulvic Acid.
  19. Bruccoleri, A., Lepore, G., Langford, C.H., (1994), Environmental Oxidants, J.O. Nriagu and M.S. Simmons (Eds.), John Wiley & Sons, Chapter 7: The Physical Chemistry of Photochemical Oxidant Generation in Natural Water Systems.
  20. Bruccoleri, A., Pant, B., Sharma, D., Langford, C.H., (1993), Evaluation of Primary Photoproduct Quantum Yields in Fulvic Acid, Environ. Science & Technology, 27, 889-894.
  21. Bruccoleri, A., Arbour, C., Langford, C.H., Pulsed Photoacoustic Evaluation of Intersystem Crossing Quantum Yields in Fulvic Acid, Environmental Technology, Vol. 11, No. 2, pp 169-173, (1990).