Publications | Center for Genomics | LLU School of Medicine

Publications in Charles Wang Lab/Center for Genomics

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Walayat A, Hosseini M, Nepal C, Li Y, Chen W, Chen Z, Huang X, Shao XM, Zhang L, Wang C, Xiao D. Maternal e-cigarette exposure alters DNA methylome, site-specific CpG and CH methylation, and transcriptomic signatures in the neonatal brain. Sci Rep. 2024 Oct 16;14(1):24263. doi: 10.1038/s41598-024-75986-x. PubMed PMID: 39414906; PubMed Central PMCID: PMC11484909.

Nepal C, Chen W, Chen Z, Wrobel JA, Xie L, Liao W, Xiao C, Farmer A, Moos M Jr, Jones W, Chen X, Wang C. Epigenomic, transcriptomic and proteomic characterizations of reference samples. bioRxiv. 2024 Sep 17;. doi: 10.1101/2024.09.09.612110. PubMed PMID: 39314461; PubMed Central PMCID: PMC11419083.

Mirshahidi S, Yuan IJ, Chen Z, Simental A, Lee SC, Andrade Filho PA, Murry T, Zeng F, Duerksen-Hughes P, Wang C, Yuan X. Tumor Cell Stemness and Stromal Cell Features Contribute to Oral Cancer Outcome Disparity in Black Americans. Cancers (Basel). 2024 Jul 31;16(15). doi: 10.3390/cancers16152730. PubMed PMID: 39123459; PubMed Central PMCID: PMC11311411.

Masood D, Ren L, Nguyen C, Brundu FG, Zheng L, Zhao Y, Jaeger E, Li Y, Cha SW, Halpern A, Truong S, Virata M, Yan C, Chen Q, Pang A, Alberto R, Xiao C, Yang Z, Chen W, Wang C, Cross F Jr, Catreux S, Shi L, Beaver JA, Xiao W, Meerzaman DM. Evaluation of somatic copy number variation detection by NGS technologies and bioinformatics tools on a hyper-diploid cancer genome. Genome Biol. 2024 Jun 20;25(1):163. doi: 10.1186/s13059-024-03294-8. PubMed PMID: 38902799; PubMed Central PMCID: PMC11188507.

Fuller RN, Vallejos PA, Kabagwira J, Liu T, Wang C, Wall NR. miRNA signatures underlie chemoresistance in the gemcitabine-resistant pancreatic ductal adenocarcinoma cell line MIA PaCa-2 GR. Front Genet. 2024;15:1393353. doi: 10.3389/fgene.2024.1393353. eCollection 2024. PubMed PMID: 38919953; PubMed Central PMCID: PMC11196613.

Suzuki T, Conant A, Jung Y, Bax R, Antonissen A, Chen W, Yu G, Ioffe YJ, Wang C, Unternaehrer JJ. A Stem-like Patient-Derived Ovarian Cancer Model of Platinum Resistance Reveals Dissociation of Stemness and Resistance. Int J Mol Sci. 2024 Mar 29;25(7). doi: 10.3390/ijms25073843. PubMed PMID: 38612653; PubMed Central PMCID: PMC11011340.

Wang S, Wu J, Chen Z, Wu W, Lu L, Cheng Y, Li S, Chen L, Tan X, Yang L, Wang C, Song Y. DNA methylation reprogramming mediates transgenerational diabetogenic effect induced by early-life p,p'-DDE exposure. Chemosphere. 2024 Feb;349:140907. doi: 10.1016/j.chemosphere.2023.140907. Epub 2023 Dec 11. PubMed PMID: 38092165.

Ximinies AD, Dou Y, Mishra A, Zhang K, Deivanayagam C, Wang C, Fletcher HM. The Oxidative Stress-Induced Hypothetical Protein PG_0686 in Porphyromonas gingivalis W83 Is a Novel Diguanylate Cyclase. Microbiol Spectr. 2023 Jan 31;11(2):e0441122. doi: 10.1128/spectrum.04411-22. Epub ahead of print. PMID: 36719196; PMCID: PMC10101095.
Kremsky I, Ma Q, Li B, Dasgupta C, Chen X, Ali S, Angeloni S, Wang C, Zhang L. Fetal hypoxia results in sex- and cell type-specific alterations in neonatal transcription in rat oligodendrocyte precursor cells, microglia, neurons, and oligodendrocytes. Cell Biosci. 2023 Mar 17;13(1):58. doi: 10.1186/s13578-023-01012-8. PMID: 36932456; PMCID: PMC10022003.
Liu T, Chen Z, Chen W, Evans R, Xu J, Reeves ME, de Vera ME, Wang C (corresponding). Dysregulated miRNAs modulate tumor microenvironment associated signaling networks in pancreatic ductal adenocarcinoma. Precis Clin Med. 2023 Mar 10;6(1):pbad004. doi: 10.1093/pcmedi/pbad004. PMID: 37007745; PMCID: PMC10052370.
Chen W, Wang C, Yang ZX, Zhang F, Wen W, Schaniel C, Mi X, Bock M, Zhang XB, Qiu H, Wang C (corresponding). Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors. Commun Biol. 2023 Apr 11;6(1):393. doi: 10.1038/s42003-023-04737-x. PMID: 37041280; PMCID: PMC10090171.
Boutrin MC, Mishra A, Wang C, Dou Y, Fletcher HM. The involvement of CdhR in Porphyromonas gingivalis during nitric oxide stress. Mol Oral Microbiol. 2023 May 3. doi: 10.1111/omi.12414. Epub ahead of print. PMID: 37134265.
Oyefeso FA, Goldberg G, Opoku NYPS, Vazquez M, Bertucci A, Chen Z, Wang C, Muotri AR, Pecaut MJ. Effects of acute low-moderate dose ionizing radiation to human brain organoids. PLoS One. 2023 May 31;18(5):e0282958. doi: 10.1371/journal.pone.0282958. PMID: 37256873; PMCID: PMC10231836.
Sanchez-Hernandez ES, Ochoa PT, Suzuki T, Ortiz-Hernandez GL, Unternaehrer JJ, Alkashgari HR, Diaz Osterman CJ, Martinez SR, Chen Z, Kremsky I, Wang C, Casiano CA. Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells. Cells. 2023 Aug 11;12(16):2046. doi: 10.3390/cells12162046. PMID: 37626856; PMCID: PMC10453226.
Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X. Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation. Cell Chem Biol. 2023 Oct 19:S2451-9456(23)00331-8. doi: 10.1016/j.chembiol.2023.09.012. Epub ahead of print. PMID: 37858336.
Mishra A, Dou Y, Wang C, Fletcher HM. Filifactor alocis enhances survival of Porphyromonas gingivalis W83 in response to H2 O2 -induced stress. Mol Oral Microbiol. 2023 Dec 1. doi: 10.1111/omi.12445. Epub ahead of print. PMID: 38041478.
Wang S, Wu J, Chen Z, Wu W, Lu L, Cheng Y, Li S, Chen L, Tan X, Yang L, Wang C, Song Y. DNA methylation reprogramming mediates transgenerational diabetogenic effect induced by early-life p,p'-DDE exposure. Chemosphere. 2023 Dec 11;349:140907. doi: 10.1016/j.chemosphere.2023.140907. Epub ahead of print. PMID: 38092165.

Wang Z, Zhang C, Warden CD, Liu Z, Yuan YC, Guo C, Wang C, Wang J, Wu X, Ermel R, Vonderfecht SL, Wang X, Brown C, Forman S, Yang Y, James You M, Chen W. Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia. Commun Biol. 2022 Apr 28;5(1):396. doi: 10.1038/s42003-022-03340-w. PMID: 35484199; PMCID: PMC9051098.
Mavingire N, Campbell P, Liu T, Wooten J, Khan S, Chen X, Matthews J, Wang C (co-corresponding), Brantley E. Aminoflavone upregulates putative tumor suppressor miR-125b-2-3p to inhibit luminal A breast cancer stem cell-like properties. Precis Clin Med. 2022 Mar 28;5(2):pbac008. doi: 10.1093/pcmedi/pbac008. PMID: 35694715; PMCID: PMC9172653.
Chen Z, Wang C, Blood A, Bragg S, Mata-Greenwood E. Renal functional, transcriptome, and methylome adaptations in pregnant Sprague Dawley and Brown Norway rats. PLoS One. 2022 Jun 16;17(6):e0269792. doi: 10.1371/journal.pone.0269792. PMID: 35709218; PMCID: PMC9202892.
Li X, Wang X, Huang R, Stucky A, Chen X, Sun L, Wen Q, Zeng Y, Fletcher H, Wang C, Xu Y, Cao H, Sun F, Li SC, Zhang X, Zhong JF. The Machine-Learning-Mediated Interface of Microbiome and Genetic Risk Stratification in Neuroblastoma Reveals Molecular Pathways Related to Patient Survival. Cancers (Basel). 2022 Jun 10;14(12):2874. doi: 10.3390/cancers14122874. PMID: 35740540; PMCID: PMC9220810.
Ma B, Melton E, Wiener R, Zhou N, Wu W, Lai L, Wang C, Costa KD, Qiu H. Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms. Hypertension.2022 Aug;79(8):1777-1788. doi: 10.1161/HYPERTENSIONAHA.121.18950. Epub 2022 Jun 29. PMID: 35766034; PMCID: PMC9308762.
Chen Z, Chen W, Li Y, Moos M Jr, Xiao D, Wang C (corresponding). Single-nucleus chromatin accessibility and RNA sequencing reveal impaired brain development in prenatally e-cigarette exposed neonatal rats. iScience. 2022 Jun 30;25(8):104686. doi: 10.1016/j.isci.2022.104686. PMID: 35874099; PMCID: PMC9304611.
Daneshgaran G, Gardner DJ, Chen HA, Niknam-Bienia S, Soundararajan V, Raghuram AC, Kim GH, Labaj P, Kreil DP, Wang C, Hong YK, Wong AK. Silicone Breast Implant Surface Texture Impacts Gene Expression in Periprosthetic Fibrous Capsules. Plast Reconstr Surg. 2023 Jan 1;151(1):85-95. doi: 10.1097/PRS.0000000000009800. Epub 2022 Oct 7. PMID: 36205692.
Yang Z, Chen Z, Lin X, Yao S, Xian M, Ning X, Fu W, Jiang M, Li N, Xiao X, Feng M, Lian Z, Yang W, Ren X, Zheng Z, Zhao J, Wei N, Lu W, Roponen M, Schaub B, Wong GWK, Su Z, Wang C (co-corresponding), Li J. Rural environment reduces allergic inflammation by modulating the gut microbiota. Gut Microbes. 2022 Jan-Dec;14(1):2125733. doi: 10.1080/19490976.2022.2125733. PMID: 36193874; PMCID: PMC9542937. 122.
Xiao C, Chen Z, Chen W, Padilla C, Colgan M, Wu W, Fang LT, Liu T, Yang Y, Schneider V, Wang C (co-corresponding), Xiao W. Personalized genome assembly for accurate cancer somatic mutation discovery using tumor-normal paired reference samples. Genome Biol. 2022 Nov 9;23(1):237. doi: 10.1186/s13059-022-02803-x. PMID: 36352452; PMCID: PMC9648002.
Talsania K, Shen TW, Chen X, Jaeger E, Li Z, Chen Z, Chen W, Tran B, Kusko R, Wang L, Pang AWC, Yang Z, Choudhari S, Colgan M, Fang LT, Carroll A, Shetty J, Kriga Y, German O, Smirnova T, Liu T, Li J, Kellman B, Hong K, Hastie AR, Natarajan A, Moshrefi A, Granat A, Truong T, Bombardi R, Mankinen V, Meerzaman D, Mason CE, Collins J, Stahlberg E, Xiao C, Wang C (co-corresponding), Xiao W, Zhao Y. Structural variant analysis of a cancer reference cell line sample using multiple sequencing technologies. Genome Biol. 2022 Dec 13;23(1):255. doi: 10.1186/s13059-022-02816-6. PMID: 36514120; PMCID: PMC9746098.

Zhang JP, Yang ZX, Zhang F, Fu YW, Dai XY, Wen W, Zhang B, Choi H, Chen W, Brown M, Baylink D, Zhang L, Qiu H, Wang C (co-corresponding), Cheng T, Zhang XB. HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs. Sci China Life Sci. 2021 Sep;64(9):1449-1462. doi: 10.1007/s11427-020-1855-4. Epub 2021 Jan 6. PMID: 33420926.
Chen X, Yang Z, Chen W, Zhao Y, Farmer A, Tran B, Furtak V, Moos M Jr, Xiao W, Wang C (corresponding). A multi-center cross-platform single-cell RNA sequencing reference dataset. Sci Data. 2021 Feb 2;8(1):39. doi: 10.1038/s41597-021-00809-x. PMID: 33531477; PMCID: PMC7854649.
Hosseini M, Chen W, Xiao D, Wang C (corresponding). Computational molecular docking and virtual screening revealed promising SARS-CoV-2 drugs. Precis Clin Med. 2021 Jan 18;4(1):1-16. doi: 10.1093/pcmedi/pbab001. PMID: 33842834; PMCID: PMC7928605.
Gong B, Li D, Kusko R, Novoradovskaya N, Zhang Y, Wang S, Pabón-Peña C, Zhang Z, Lai K, Cai W, LoCoco JS, Lader E, Richmond TA, Mittal VK, Liu LC, Johann DJ Jr, Willey JC, Bushel PR, Yu Y, Xu C, Chen G, Burgess D, Cawley S, Giorda K, Haseley N, Qiu F, Wilkins K, Arib H, Attwooll C, Babson K, Bao L, Bao W, Lucas AB, Best H, Bhandari A, Bisgin H, Blackburn J, Blomquist TM, Boardman L, Burgher B, Butler DJ, Chang CJ, Chaubey A, Chen T, Chierici M, Chin CR, Close D, Conroy J, Cooley Coleman J, Craig DJ, Crawford E, Del Pozo A, Deveson IW, Duncan D, Eterovic AK, Fan X, Foox J, Furlanello C, Ghosal A, Glenn S, Guan M, Haag C, Hang X, Happe S, Hennigan B, Hipp J, Hong H, Horvath K, Hu J, Hung LY, Jarosz M, Kerkhof J, Kipp B, Kreil DP, Łabaj P, Lapunzina P, Li P, Li QZ, Li W, Li Z, Liang Y, Liu S, Liu Z, Ma C, Marella N, Martín-Arenas R, Megherbi DB, Meng Q, Mieczkowski PA, Morrison T, Muzny D, Ning B, Parsons BL, Paweletz CP, Pirooznia M, Qu W, Raymond A, Rindler P, Ringler R, Sadikovic B, Scherer A, Schulze E, Sebra R, Shaknovich R, Shi Q, Shi T, Silla-Castro JC, Smith M, López MS, Song P, Stetson D, Strahl M, Stuart A, Supplee J, Szankasi P, Tan H, Tang LY, Tao Y, Thakkar S, Thierry-Mieg D, Thierry-Mieg J, Thodima VJ, Thomas D, Tichý B, Tom N, Garcia EV, Verma S, Walker K, Wang C, Wang J, Wang Y, Wen Z, Wirta V, Wu L, Xiao C, Xiao W, Xu S, Yang M, Ying J, Yip SH, Zhang G, Zhang S, Zhao M, Zheng Y, Zhou X, Mason CE, Mercer T, Tong W, Shi L, Jones W, Xu J. Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions. Genome Biol. 2021 Apr 16;22(1):109. doi: 10.1186/s13059-021-02315-0. PMID: 33863344; PMCID: PMC8051090.
Chen Z, Stanbouly S, Nishiyama NC, Chen X, Delp MD, Qiu H, Mao XW, Wang C (corresponding). Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina. Precis Clin Med. 2021 May 17;4(2):93-108. doi: 10.1093/pcmedi/pbab012. PMID: 34179686; PMCID: PMC8220224.
Liu T, Chen Z, Chen W, Chen X, Hosseini M, Yang Z, Li J, Ho D, Turay D, Gheorghe CP, Jones W, Wang C (corresponding). A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples. iScience. 2021 Aug 20;24(8):102892. doi: 10.1016/j.isci.2021.102892. Epub 2021 Jul 21. PMID: 34308277; PMCID: PMC8294598.
Gatto NM, Garcia-Cano J, Irani C, Jaceldo-Siegl K, Liu T, Chen Z, Paul J, Fraser G, Wang C, Lee GJ. Vegetarian Dietary Patterns and Cognitive Function among Older Adults: The Adventist Health Study-2. J Nutr Gerontol Geriatr. 2021 Oct-Dec;40(4):197-214. doi: 10.1080/21551197.2021.1965939. Epub 2021 Aug 19. PMID: 34412570.
Wu W, Sun X, Shi X, Lai L, Wang C, Xie M, Qin G, Qiu H. Hsp22 Deficiency Induces Age-Dependent Cardiac Dilation and Dysfunction by Impairing Autophagy, Metabolism, and Oxidative Response. Antioxidants (Basel). 2021 Sep 29;10(10):1550. doi: 10.3390/antiox10101550. PMID: 34679684; PMCID: PMC8533440.
Chen W, Zhao Y, Chen X, Yang Z, Xu X, Bi Y, Chen V, Li J, Choi H, Ernest B, Tran B, Mehta M, Kumar P, Farmer A, Mir A, Mehra UA, Li JL, Moos M Jr, Xiao W, Wang C (corresponding). A multicenter study benchmarking single-cell RNA sequencing technologies using reference samples. Nat Biotechnol. 2021 Sep;39(9):1103-1114. doi: 10.1038/s41587-020-00748-9. Epub 2020 Dec 21. PMID: 33349700. Received the Best Paper Award, at the 2021 MAQC Society Annual Meeting.
Xiao W, Ren L, Chen Z, Fang LT, Zhao Y, Lack J, Guan M, Zhu B, Jaeger E, Kerrigan L, Blomquist TM, Hung T, Sultan M, Idler K, Lu C, Scherer A, Kusko R, Moos M, Xiao C, Sherry ST, Abaan OD, Chen W, Chen X, Nordlund J, Liljedahl U, Maestro R, Polano M, Drabek J, Vojta P, Kõks S, Reimann E, Madala BS, Mercer T, Miller C, Jacob H, Truong T, Moshrefi A, Natarajan A, Granat A, Schroth GP, Kalamegham R, Peters E, Petitjean V, Walton A, Shen TW, Talsania K, Vera CJ, Langenbach K, de Mars M, Hipp JA, Willey JC, Wang J, Shetty J, Kriga Y, Raziuddin A, Tran B, Zheng Y, Yu Y, Cam M, Jailwala P, Nguyen C, Meerzaman D, Chen Q, Yan C, Ernest B, Mehra U, Jensen RV, Jones W, Li JL, Papas BN, Pirooznia M, Chen YC, Seifuddin F, Li Z, Liu X, Resch W, Wang J, Wu L, Yavas G, Miles C, Ning B, Tong W, Mason CE, Donaldson E, Lababidi S, Staudt LM, Tezak Z, Hong H, Wang C (co-corresponding), Shi L. Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing. Nat Biotechnol. 2021 Sep;39(9):1141-1150. doi: 10.1038/s41587-021-00994-5. Epub 2021 Sep 9. PMID: 34504346; PMCID: PMC8506910.
Fang LT, Zhu B, Zhao Y, Chen W, Yang Z, Kerrigan L, Langenbach K, de Mars M, Lu C, Idler K, Jacob H, Zheng Y, Ren L, Yu Y, Jaeger E, Schroth GP, Abaan OD, Talsania K, Lack J, Shen TW, Chen Z, Stanbouly S, Tran B, Shetty J, Kriga Y, Meerzaman D, Nguyen C, Petitjean V, Sultan M, Cam M, Mehta M, Hung T, Peters E, Kalamegham R, Sahraeian SME, Mohiyuddin M, Guo Y, Yao L, Song L, Lam HYK, Drabek J, Vojta P, Maestro R, Gasparotto D, Kõks S, Reimann E, Scherer A, Nordlund J, Liljedahl U, Jensen RV, Pirooznia M, Li Z, Xiao C, Sherry ST, Kusko R, Moos M, Donaldson E, Tezak Z, Ning B, Tong W, Li J, Duerken-Hughes P, Catalanotti C, Maheshwari S, Shuga J, Liang WS, Keats J, Adkins J, Tassone E, Zismann V, McDaniel T, Trent J, Foox J, Butler D, Mason CE, Hong H, Shi L, Wang C (co-corresponding), Xiao W; Somatic Mutation Working Group of Sequencing Quality Control Phase II Consortium. Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing. Nat Biotechnol. 2021 Sep;39(9):1151-1160. doi: 10.1038/s41587-021-00993-6. Epub 2021 Sep 9. PMID: 34504347; PMCID: PMC8532138.
Liu MM, Liu T, Yeung S, Wang Z, Andresen B, Parsa C, Orlando R, Zhou B, Wu W, Li X, Zhang Y, Wang C (co-corresponding), Huang Y. Inhibitory activity of medicinal mushroom Ganoderma lucidum on colorectal cancer by attenuating inflammation. Precis Clin Med. 2021 Aug 28;4(4):231-245. doi: 10.1093/pcmedi/pbab023. PMID: 35692861; PMCID: PMC8982591.
Rood K, Begum K, Wang H, Wangworawat YC, Davis R, Yamauchi CR, Perez MC, Simental AA, Laxa RT, Wang C, Roy S, Khan S. Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups. Curr Oncol. 2021 Sep 19;28(5):3610-3628. doi: 10.3390/curroncol28050309. PMID: 34590612; PMCID: PMC8482137.
Foox J, Nordlund J, Lalancette C, Gong T, Lacey M, Lent S, Langhorst BW, Ponnaluri VKC, Williams L, Padmanabhan KR, Cavalcante R, Lundmark A, Butler D, Mozsary C, Gurvitch J, Greally JM, Suzuki M, Menor M, Nasu M, Alonso A, Sheridan C, Scherer A, Bruinsma S, Golda G, Muszynska A, Łabaj PP, Campbell MA, Wos F, Raine A, Liljedahl U, Axelsson T, Wang C, Chen Z, Yang Z, Li J, Yang X, Wang H, Melnick A, Guo S, Blume A, Franke V, Ibanez de Caceres I, Rodriguez-Antolin C, Rosas R, Davis JW, Ishii J, Megherbi DB, Xiao W, Liao W, Xu J, Hong H, Ning B, Tong W, Akalin A, Wang Y, Deng Y, Mason CE. The SEQC2 epigenomics quality control (EpiQC) study. Genome Biol. 2021 Dec 6;22(1):332. doi:10.1186/s13059-021-02529-2. Erratum in: Genome Biol. 2021 Dec 23;22(1):350. Erratum in: Genome Biol. 2022 Mar 8;23(1):76. PMID: 34872606; PMCID: PMC8650396.
Zhao Y, Fang LT, Shen TW, Choudhari S, Talsania K, Chen X, Shetty J, Kriga Y, Tran B, Zhu B, Chen Z, Chen W, Wang C, Jaeger E, Meerzaman D, Lu C, Idler K, Ren L, Zheng Y, Shi L, Petitjean V, Sultan M, Hung T, Peters E, Drabek J, Vojta P, Maestro R, Gasparotto D, Kõks S, Reimann E, Scherer A, Nordlund J, Liljedahl U, Foox J, Mason CE, Xiao C, Hong H, Xiao W. Whole genome and exome sequencing reference datasets from a multi-center and cross-platform benchmark study. Sci Data. 2021 Nov 9;8(1):296. doi: 10.1038/s41597-021-01077-5. PMID: 34753956; PMCID: PMC8578599.

Chen X, Zhang L, Wang C (corresponding). Prenatal hypoxia-induced epigenomic and transcriptomic reprogramming in rat fetal and adult offspring hearts. Sci Data. 2019 Oct 29;6(1):238. doi: 10.1038/s41597-019-0253-9. PMID: 31664036; PMCID: PMC6820751.
Zhou N, Chen X, Xi J, Ma B, Leimena C, Stoll S, Qin G, Wang C (co-corresponding), Qiu H. Genomic characterization reveals novel mechanisms underlying the valosin-containing protein-mediated cardiac protection against heart failure. Redox Biol. 2020 Sep;36:101662. doi: 10.1016/j.redox.2020.101662. Epub 2020 Jul 30. PMID: 32795937; PMCID: PMC7426568.
Gatto NM, Garcia-Cano J, Irani C, Liu T, Arakaki C, Fraser G, Wang C, Lee GJ. Observed Physical Function Is Associated with Better Cognition among Elderly Adults: The Adventist Health Study-2. Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317520960868. doi: 10.1177/1533317520960868. PMID: 32996324.
Lin X, Ren X, Xiao X, Yang Z, Yao S, Wong GW, Liu Z, Wang C, Su Z, Li J. Important Role of Immunological Responses to Environmental Exposure in the Development of Allergic Asthma. Allergy Asthma Immunol Res. 2020 Nov;12(6):934-948. doi: 10.4168/aair.2020.12.6.934. PMID: 32935487; PMCID: PMC7492518.
Zhou N, Chen X, Xi J, Ma B, Leimena C, Stoll S, Qin G, Wang C (co-corresponding), Qiu H. Novel genomic targets of valosin-containing protein in protecting pathological cardiac hypertrophy. Sci Rep. 2020 Oct 22;10(1):18098. doi: 10.1038/s41598-020-75128-z. PMID: 33093614; PMCID: PMC7582185.
Chang E, Fu C, Coon SL, Alon S, Bozinoski M, Breymaier M, Bustos DM, Clokie SJ, Gothilf Y, Esnault C, Michael Iuvone P, Mason CE, Ochocinska MJ, Tovin A, Wang C, Xu P, Zhu J, Dale R, Klein DC. Resource: A multi-species multi-timepoint transcriptome database and webpage for the pineal gland and retina. J Pineal Res. 2020 Oct;69(3):e12673. doi: 10.1111/jpi.12673. Epub 2020 Jul 8. PMID: 32533862; PMCID: PMC7513311.
Filippov V, Jaceldo-Siegl K, Eroshkin A, Loskutov V, Chen X, Wang C, Duerksen-Hughes PJ. Methylomes in Vegans versus Pescatarians and Nonvegetarians. Epigenomes. 2020 Dec;4(4):28. doi: 10.3390/epigenomes4040028. Epub 2020 Dec 11. PMID: 33768971; PMCID: PMC7990391.
Miles FL, Mashchak A, Filippov V, Orlich MJ, Duerksen-Hughes P, Chen X, Wang C, Siegmund K, Fraser GE. DNA Methylation Profiles of Vegans and Non-Vegetarians in the Adventist Health Study-2 Cohort. Nutrients. 2020 Nov 30;12(12):3697. doi: 10.3390/nu12123697. PMID: 33266012; PMCID: PMC7761449.
Siddiqui SS, Vaill M, Do R, Khan N, Verhagen AL, Zhang W, Lenz HJ, Johnson-Pais TL, Leach RJ, Fraser G, Wang C, Feng GS, Varki N, Varki A. Human-specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression. FASEB Bioadv. 2020 Dec 8;3(2):69-82. doi: 10.1096/fba.2020-00092. PMID: 33615152; PMCID: PMC7876704.
Liu T, Gatto NM, Chen Z, Qiu H, Lee G, Duerksen-Hughes P, Fraser G, Wang C (corresponding). Vegetarian diets, circulating miRNA expression and healthspan in subjects living in the Blue Zone. Precis Clin Med. 2020 Dec;3(4):245-259. doi: 10.1093/pcmedi/pbaa037. Epub 2020 Oct 23. PMID: 33391847; PMCID: PMC7757436.

Huang L, Chen X, Dasgupta C, Chen W, Song R, Wang C (co-corresponding), Zhang L. Foetal hypoxia impacts methylome and transcriptome in developmental programming of heart disease. Cardiovasc Res. 2019 Jul 1;115(8):1306-1319. doi: 10.1093/cvr/cvy277. PMID: 30395198; PMCID: PMC6587923.
Johnson MB, Niknam-Bienia S, Soundararajan V, Pang B, Jung E, Gardner DJ, Xu X, Park SY, Wang C, Chen X, Baker RY, Chen M, Hong YK, Li W, Wong AK. Mesenchymal Stromal Cells Isolated from Irradiated Human Skin Have Diminished Capacity for Proliferation, Differentiation, Colony Formation, and Paracrine Stimulation. Stem Cells Transl Med. 2019 Sep;8(9):925-934. doi: 10.1002/sctm.18-0112. Epub 2019 Apr 24. PMID: 31020798; PMCID: PMC6708065.
Overbey EG, da Silveira WA, Stanbouly S, Nishiyama NC, Roque-Torres GD, Pecaut MJ, Zawieja DC, Wang C, Willey JS, Delp MD, Hardiman G, Mao XW. Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina. Sci Rep. 2019 Sep 16;9(1):13304. doi: 10.1038/s41598-019-49453-x. PMID: 31527661; PMCID: PMC6746706.
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